Welcome to the Sundquist Lab


Structure of the LIP5(MIT)2-CHMP5139-195 complex (J Biol Chem Oct 2012) 3D reconstruction of CHMP2A-CHMP3 tubes (column pattern, n=6) (Cell Microbiol Oct 2012) Human cytomegalovirus major immediate early enhancer/promoter constructs used for attenuated gene expression Global view of of the BM 4 inhibitor (sticks) bound to the CA hexamer (surface model, with different CA subunits in different colors, and N-terminal domains shown in darker shades) (J Virol June 2011) Close-up view of a single CANTD/CACTD interface (boxed in panel A) showing how a BM 4 inhibitor bound to the CANTD (yellow) would be positioned to perturb the interface with an adjacent CACTD (red) (J Virol June 2011) Thin-sectioned, transmission electron micrographs of arrested HIV-1 budding particles in cells lacking CHMP2A/B (Cell Host Microbe 2011 March) Homology model of CHMP2A showing mutations that blocked binding of CHMP4B (Cell Host Microbe 2011 March) Network representation of HIV–human protein-protein interactions (Nature 2011 December 21) Structure of Human BROX and Comparison with the ALIX Bro1 Domain (PLoS One 2011 Dec 5) Model depicting different stages of ALIX activation (J Virol 2011 June 29) Hexagonal assembly of TRIM5-21R, a restrictive variant of TRIM5α-rhesus (Proc Natl Acad Sci 2011 Jan 11) HIV-1 capsid mimics promote TRIM5-21R assembly (Proc Natl Acad Sci 2011 Jan 11) A lattice complementarity model for retroviral capsid recognition by TRIM5α (Proc Natl Acad Sci 2011 Jan 11) Representative biosensor sensograms for ALIXBro1-V binding to GST-p6Gag proteins from HIV and SIV (J Virol. 2011 Jan;85(1):632-7) Structures of SIV late domains bound to ALIX. (A) SIVmac239 p6Gag peptide (B) SIVagmTam-1 p6Gag peptide (J Virol. 2011 Jan;85(1):632-7) (A) Primary sequence analysis of late domains within primate lentiviral p6Gag proteins. (B) ALIX overexpression stimulated release of a SIVmac251 ΔPTAP construct. (J Virol. 2011 Jan;85(1):632-7) Structure of reduced BST2(47–152). The four molecules in the asymmetric unit. Yellow/magenta and blue/green subunits form parallel dimers. (Proc Natl Acad Sci U S A. 2010 Sep 29) Structure of oxidized BST2(51–151). Overlap of the reduced (green) and oxidized (orange) structures (Proc Natl Acad Sci U S A. 2010 Sep 29) Inhibition of HIV-1 infectivity by BST2 proteins. Graph showing HIV-1 titers in the presence of increasing quantities of expression vectors. Wild-type BST2 (light curve), BST2(L70D) (dark curve). (Proc Natl Acad Sci U S A. 2010 Sep 29)
Opal Allen, Ph.D.Yen-li Li John McCullough, Ph.D. Steve Alam, Ph.D. Nicole Monroe, Ph.D.Jack Skalicky, Ph.D.Dawn Wenzel, Ph.D. Devin Christensen, Ph.D. Matt Lalonde, Ph.D.Joerg Votteler, Ph.D.Lauren Williams Tuscan Thompson Matt Miller Lara Rheinemann Patrick McCullagh Ruth Pumroy, Ph.D. Kendall Denning